JACKSONVILLE, Fla. (AP) - The Indianapolis Colts were manhandled by the Jacksonville Jaguars 44-17. The Jags won the game with an overwhelming rushing game. Rookie Maurice Jones-Drew ran for a career-high 166 yards and two scores while Fred Taylor carried the ball for 131 yards. The Colts allowed a franchise record 373 yards rushing in the loss. The win is the first for the Jags over the Colts since 2004 and gives them eight wins and five defeats this season. The loss, which leaves the Colts at 10-3, puts Indianapolis' hopes of claiming home field advantage in the AFC in jeopardy. Marvin Harrison of the Colts had another fine day with six receptions for 101 yards. He becomes just the fourth player in league history with one thousand receptions, joining Jerry Rice, Tim Brown and Cris Carter. Peyton Manning of the Colts finished with 313 yards passing on 25 of 50 passing.